NF-Y and USF1 transcription factor binding to CCAAT-box and E-box elements activates the CP27 promoter
نویسندگان
چکیده
منابع مشابه
CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factors.
NF-Y binds a CCAAT motif found in many eukaryotic polymerase II-dependent promoters. In the HLA-DRA promoter it has been demonstrated that stereo-specific alignment between this motif and the upstream elements X1 and X2 is required for activation. To study the underlying mechanism for this requirement, a panel of transfected cell lines that maintained integrated, wild-type and mutant promoters ...
متن کاملTranscriptional regulation of cellular ageing by the CCAAT box-binding factor CBF/NF-Y.
Cellular ageing is a systematic process affecting the entirety of cell structure and function. Since changes in gene expression are extensive and global during ageing, involvement of general transcription regulators in the phenomenon is likely. Here, we focus on NF-Y, the major CCAAT box-binding factor, which exerts differential regulation on a wide variety of genes through its interaction with...
متن کاملEvolutionary variation of the CCAAT-binding transcription factor NF-Y.
NF-Y is a CCAAT-specific transcription factor thought to be involved in the regulation of a variety of eukaryotic genes. It shows a striking sequence similarity with the yeast factor HAP2/3. In an attempt to trace back its evolutionary history, we succeeded in isolating NF-Y cDNA clones from a plant and from several species of vertebrates. The patterns of sequence conservation delineate potenti...
متن کاملThe CCAAT box binding factor, NF-Y, is required for thyroid hormone regulation of rat liver S14 gene transcription.
Triiodothyronine (T3) activates rat liver S14 gene transcription through T3 receptors (TRbeta) binding distal thyroid hormone response elements located between -2.8 and -2.5 kilobase pairs upstream from the transcription start site. Previous studies suggested that proximal promoter elements located between -220 to -80 base pairs upstream from the 5' end of the S14 gene were involved in hormone ...
متن کاملThe CCAAT box-binding transcription factor NF-YA1 controls rhizobial infection
Symbiosis between legume plants and soil rhizobia culminates in the formation of a novel root organ, the 'nodule', containing bacteria differentiated as facultative nitrogen-fixing organelles. MtNF-YA1 is a Medicago truncatula CCAAT box-binding transcription factor (TF), formerly called HAP2-1, highly expressed in mature nodules and required for nodule meristem function and persistence. Here a ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gene
سال: 2011
ISSN: 0378-1119
DOI: 10.1016/j.gene.2010.11.001